Future Trends in Hair Restoration

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Although today’s available treatment options for hair loss can provide improvements for many hair loss sufferers, there are no therapies which can create brand new hair follicles and expand the supply of hair. That may change soon. A new supply source of hair follicles would revolutionize the treatment options for people suffering from hair loss and open the possibility of full hair restoration regardless of the degree of hair loss.

Scientific advances over the last decade have made cell-based therapies possible, thus opening a potential path to generate de novo hair follicles – a new supply. Cell therapies differ from traditional medicine in that they use living cells, rather than a drug molecule, to treat the target condition. Cell therapies are most often derived from special stem cells. These stem cells have three important properties offering therapeutic value.

  1. The power to be “programmed” to perform a specific purpose inside the human body
  2. The power to differentiate into any cell type in the human body, thus offering a new source of the cell type needed for a specific medical condition
  3. The power to proliferate and regenerate lost or damaged tissue and organs

These three unique capabilities give cell therapies the potential to treat a broad range of diseases and injuries. For example, the power to be “programmed” for specific purposes is being used to develop special immune cells programmed to target and kill cancer tumors. The power to differentiate into any cell type is being used to generate new pancreatic islet cells to treat Type 1 Diabetes. The power to proliferate and regenerate is being used to create new spinal cord cells to heal damaged spines. And these capabilities also open the path for a cell therapy which can generate new hair.

Stemson Therapeutics was formed in 2018 to develop a cell therapy solution targeting hair loss. Stemson’s stem cell technology was created at the Sanford Burnham Prebys Medical Discovery Institute by Stemson co-founder Dr. Alexey Terskikh, a renowned cell biologist and regenerative medicine scientist. Fresh hair follicle donations from Dr. Richard Chaffoo and his patients played a vital role in supporting Dr. Terskikh’s basic research to develop the solution. After Dr. Terskikh achieved critical milestones demonstrating a viable solution for hair loss, Stemson Therapeutics was created to commercialize the cell therapy. Dr. Chaffoo serves as medical advisor and Medical Director for the company. Stemson’s solution uses Induced Pluripotent Stem Cells (iPSC) to recreate the two cell types required to generate a hair follicle – Dermal Papilla.

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Hair growth in nude mice transplanted with human iPSC-derived dermal papillae cells that were combined with mouse epithelial cells.

(DP) cells and Epithelial Stem (EpS) cells. iPSC have the power to proliferate indefinitely and to become any cell type in the human body. Dr. Terskikh was the first to determine how to differentiate iPSC into the DP and EpS cells required for hair growth. The DP and EpS cells work together to initiate hair follicle formation and grow the hair shaft. The solution has shown tremendous promise by successfully growing de novo human hair follicles in animals using the iPSC-derived DP and EpS cells created in the lab. Stemson is planning human clinical trials within the next few years with a goal to release a cell therapy which will provide an unlimited supply of new hair follicle to patients.

The research team from Stemson Therapeutics recently presented their research findings at the 2019 Annual Meeting of the International Society for Stem Cell Research (ISSCR) in Los Angeles, California, which is co-sponsored by the University of Southern California (USC). This groundbreaking research has created intense interest with both the national and international news services including the London Daily Telegraph, New York Times, Los Angeles Times, and many others.

For more information on Stemson Therapeutics, please visit their website at https://www.stemsontx.com/.

For a copy of the new book on hair loss solutions authored by Drs. Chaffoo and Stuart, visit Amazon.

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